Association between high sensitivity C-reactive protein and coronary atherosclerosis in a general middle-aged population

Abstract Background Despite abundant knowledge about the relationship between inflammation and coronary artery disease (CAD), it is still unknown whether high sensitivity C-reactive protein (hsCRP) associated with atherosclerosis in general population. Objectives The project aimed to study association systemic inflammation, measured as hsCRP, a large population based cohort. Methods 30,154 randomly selected men women aged 50 64 years were included SCAPIS (Swedish Cardiopulmonary Bioimage Study). After excluding those not undergoing computed tomography angiography (CCTA), proximal segments technically assessable missing values of 25,408 individuals analysed. Coronary was defined presence plaque any degree (1–49% or ≥50% diameter stenosis) due calcification 18 segments. Analysis severe participants stenosis left main (LMCA), anterior descending (LAD) three vessel including each LAD, right (RCA) circumflex (CX). Participants hsCRP above lowest detection limit (≥0.7mg/L) divided into tertiles compared hsCRP<0.7 mg/L reference. Results highest tertile measurable (≥2.3 mg/L) multivariate analysis adjusted for classical cardiovascular risk factors (Table 1). HsCRP also related significant ≥50%, ≥4 involved, noncalcified plaques. Also, moderately elevated (1.2–2.2 In stratified analysis, two (≥1.2 women, but men. Conclusion Elevated prevalence cohort middle-aged women. relationships more pronounced plaques This suggests that attention should be given assessment without known disease, especially Funding Acknowledgement Type funding sources: Foundation. Main source(s): Swedish Heart Lung FoundationKnut Alice Wallenberg Foundation